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//////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// /////////////////////////wMAAAAAAA== ------=_NextPart_01C5C2C5.E1FDCE20 Content-Location: file:///C:/0D27C959/OptimizedWang_Toxicology_files/master11.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
Click to edit Master title style=
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------=_NextPart_01C5C2C5.E1FDCE20 Content-Location: file:///C:/0D27C959/OptimizedWang_Toxicology_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C5C2C5.E1FDCE20 Content-Location: file:///C:/0D27C959/OptimizedWang_Toxicology_files/slide0036.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills
Toxicology and Risk of Fumiga= nts to Workers and the General Public <= /span>
Dong Wang, Ph.D.
University of Minnesota
St. Paul, Minnesota
<= span style=3D'font-family:"Times New Roman";font-size:56%;color:#333399;mso-col= or-index: 3'>nPhysico-chem properties of fumiga= nts and mode of entry
nToxicological issues
= nOffsite transport and risk
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Soil Fumigation
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Scope of this Talk
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Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills
Alternative Fumigants
Methyl isothiocyanate (MITC)
Chloropicrin (CP)
1,3-Dichloropropene (1,3-D)
Methyl Iodide (MI)
C =3D C= - C - Cl
Cl
H
H
H
H3C-I
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Physico-chemical properties of fumigants
53
3.7
3.2
2.1
Vapor Press (kPa)
0.54
0.21
0.33
0.02
Henry’s Constant (kPa m3/mol)
14
142
MI§<= /span>
2.0
111
1,3-D
1.6
164
CP
8.2
Water Sol (g/L)
73
MW (g/mol)&#= 13;
MITC
<= /div>
Dowling and Seiber (= 2002) Intern. J. Toxicol. 21:371-381;  §Gan and Yates (1996).
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Pesticides’ Mode of Entry into Organisms
Designed to both water soluble (acid group) and lipids soluble (C group)
= Positively charged,  surfactant effect
Respiratory pores/lungs: water coating
= Organic soap effect
Dermal entry: leaf wax coating, <= span style=3D'mso-tab-count:1;width:30.5%'> human oily skins
Oral with food or by kids
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Pesticides’ Mode of Action after Entry
Designed to both water soluble (acid group) and lipids soluble (C group)
= Respiratory pores
= Dermal absorption
DNA
Mutation cancer
Cell damage/mortali= ty
cell-
-
P+ = ;
P+ = ;
P+ = ;
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charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills
Toxicological Information – Lab Rats (LD50)
---
76
221 (4hr)
MI 4
---
470-713
494
1,3-D 3
100
37
26
CP 2
33-202
Dermal (ppm)
55-220
Oral (ppm)
628
Inhalation (ppm 1hr)
MITC 1
<= /div>
1MSD= S-AMVAC (2004), Pruett et al. (2001);  2 CDPR (1999); 3 DAS (2001); 4 USEPA (2004).
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Human exposure guidance levels (mg/m3)
---
---
29
66
Acute (1 hr)
---
---
---
0.45
Chronic (lifetime)
---
28,000
10,000
MI§<= /span>
20
---
4,500
1,3-D
---
700
670
CP
---
EPA RfC (lifetime)
---
OSHA PEL
---
ACGIH TLV&#= 13;
MITC
<= /div>
Dowling and Seiber (= 2002) Intern. J. Toxicol. 21:371-381;  §USEPA (1999).
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Mechanisms of Respiratory Toxicity
1.Physical journey to = the lung
2.Biochemical / cellul= ar mechanisms
<= span style=3D'font-family:"Times New Roman";font-size:56%'>nAdult human lung has= about 40-120 m2 of surface area =
<= span style=3D'font-family:"Times New Roman";font-size:56%'>nThis surface exposed= to 10,000 – 20,000 liters of air per day
<= span style=3D'font-family:"Times New Roman";font-size:56%'>nSubstantial defenses= have evolved in the mammalian lung
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vhf/AIqj/hPdK/597z/vhf8A4qgDmKKx/wDhJrL/AJ5T/wDfI/xooA//2Q== ------=_NextPart_01C5C2C5.E1FDCE20 Content-Location: file:///C:/0D27C959/OptimizedWang_Toxicology_files/slide0082.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills
Respiratory Defense Mechanisms
1.Filtration system
n= Nose and upper airwa= ys (trachea and bronchi)
n= Mucociliary clearance mechanism
nAirways lined with m= ucous and cilia
= nTransport/drain into throat and ultimately swallowed or expectorated
2.Anti-microbial system
= n= Chemicals that reach oxygen-absorbing surface of lung removed by macrophages
= nCarry chemicals up t= he airways towards mucociliary clearance system, or
= nMigrate through the alveolar wall into lung’s internal clearance channels (lymphatic vessels) which drain in lymph nodes
n <= /div>
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Toxicological Effects on Lab Animals
---
---
Rat: no pup
No effects
Reproductive
Rats: observed
Microbes:   DNA damage
Bacteria
Some in vitro in lab animals
Mutagenicity
Rats/mice: tumors in lung
---
MI 4<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
Rats/mice: tumors in lung, liver, bladder
Rats: delayed ossification of vertebral centra
1,3-D 3<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
---
Rat/rabbit inhalation body var
CP 2<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
Rats/mice:
blood vessel tumors
Carcinogenic
Rats: observed
Developmental
MITC 1<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
<= /div>
1MSD= S-AMVAC (2004), Pruett et al. (2001);  2 CDPR (1999); 3 DAS (2001); 4 USEPA (2004).
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Adverse Health Effects – A Common Misconception
n = Least adverse effects occur at low exposure concentrations, and adverse effects occur only at high concentrations ???
Cavieres, Jaeger, Porter (2002) Env Health Perspectives 110:1081-1085 =
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file:///C:/0D27C959/OptimizedWang_Toxicology_files/slide0104.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills
Adverse Health Effects – Societal Impacts
n 5 Point IQ Shift = in Children ???
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Worker Exposure and Risk
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nProximity to sources=
nOutdoor vs Indoor: fumigants can penetrate effectively into buildings
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Toxicological Effects on Humans
No data
No data
No effect
Embryo loss
Reproductive
---
Mutagen in microbes
---
---
Mutagenicity
Tumors in mice, rats
No data
MI 4<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
Probable
---
1,3-D 3<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
Inconclusive: lack of data
---
 
CP 2<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
Probable
Carcinogenic
Reduced
fetal wt
Developmental
MITC 1<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
<= /div>
1MSD= S-AMVAC (2004), Pruett et al. (2001);  2 CDPR (1999); 3 DAS (2001); 4 USEPA (2004).
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Worker Exposure and Risk
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Health Effects on Humans
Adverse effects:=   kidney, ctrl nerv systems =
---
Adverse effects: hear, kidney, =
liver, ctrl nerv systems
Above+ wt loss, blurred vision, w/ alcohol->low blood pressure hi heart rate
Chronic overexposure
Depression of ctrl nerv systems, lung, skin irritation
MI 4<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
Skin-eye injuries
1,3-D 3<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
Vision  damage, cough, nausea, vomiting
CP 2<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
Skin-eye irritation, cramps, nausea, vomiting
Acute overexposure
MITC 1<= span style=3D'mso-bidi-font-family:"Times New Roman"'> = ;
<= /div>
1MSD= S-AMVAC (2004), Pruett et al. (2001);  2 CDPR (1999); 3 DAS (2001); 4 USEPA (2004).
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Fumigant Emission, Offsite Transport, and Risk
“Gone with the wind” – Convection
  Flux =3D Co= nc x Wind-speed
“Spreading” – Diffusion
  Rate =3D D<= /span>g x Conc-gradi= ent
Gas Transport 10= 1
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Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills
Fumigant Emission, Offsite Transport, and Risk
=       If a 20-ac fumigated field is 10 mile from a city boundary, the peak emission = released 2.6 g/m2 CP gas (at 60 ug/m2/s within 12 hrs).  The wind spe= ed is 3 mi= le/hr towards the city.  The gas is highly diffusive, and its diffusion coefficient in air is 2400 (m2/s). When the g= as will reach the city boundary?  What will be the maximum concentra= tion observed at the city boundary and when will it occur?
Wang et al. (2005) C= JFR.
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Instantaneous point source Q = (M or M/ m2) at t=3D0 in a uniform wind of speed (u)
m/s
1.3
u =3D
m2/s
2400
D =3D
m
16000
z =3D
g/m2
2.6
Qg =3D
Fumigant Emission, Offsite Transport, and Risk
When the gas will reach the city boundary?
What will be the maximum concentration at the city boundary and when it will occur?
ppmv
 =3D     20
        = ;   
ug/m3
=3D    140
Conc
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The Variable Wind and Temperature
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Fumigant Emission, Offsite Transport, and Risk
Exposure Probability (wind field, temperature, dosage)
Distance from treated field(s)
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file:///C:/0D27C959/OptimizedWang_Toxicology_files/slide0058.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills
Fumigant Emission, Offsite Transport, and Risk
Cryer et al. (2003) = J. Ag Food Chem. 51:3401-09.
ANOVA Explainable Variances in Ambient 1,3-D Concentration
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Take home message
<= span style=3D'font-family:"Times New Roman";font-size:56%'>nReduce emission &= #8211; effective surface containment (VIF), efficient delivery (chemiga= tion), soil factors (moisture, temperature, organic matter, etc.)
<= span style=3D'font-family:"Times New Roman";font-size:56%'>nUse minimal effec= tive dosage – understanding the diseases
nTiming of fumigat= ion – select low diffusive and convective conditions (NWS, = ASOS, CIMIS)
n
<= span style=3D'font-family:"Times New Roman";font-size:56%'>nProtecting the wo= rkers – use appropriate gears: respirators (unless you can= hold the breath for hours on); chem resistant coveralls, gloves, boots, goggles; washing before food intake.
nProtecting the pu= blic – safe distance “buffer zones” vs urban encroachment, ag-residential monitoring network, warning systems,  emergency plan
n
<= span style=3D'font-family:"Times New Roman";font-size:56%'>nIPM approaches (Barrasicas, crop rotation)
------=_NextPart_01C5C2C5.E1FDCE20 Content-Location: file:///C:/0D27C959/OptimizedWang_Toxicology_files/slide0097.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills
Growers, Researchers, Policy makers&#= 13;
3D"Thank
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fTrans=3Dg_showAnimation && SldHasTrans() if( fTrans )=09 { if( g_bgSound ) { idx=3Dg_bgSound.indexOf(","); pptSound.src=3Dg_bgSound.substr( 0, idx ); pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1))); } SlideObj.filters.revealtrans.Apply()=09 } SlideObj.style.visibility=3D"visible" if( fTrans ) SlideObj.filters.revealtrans.Play() } function MakeNotesVis()=20 { if( !IsNts() ) return false=20 SlideObj.style.display=3D"none" nObj =3D document.all.item("NotesObj") parent.SetHasNts(0) if( nObj ) {=20 nObj.style.display=3D"" parent.SetHasNts(1) } return 1 } function ChkAutoAdv() { if(SldHasTrans()) SlideObj.onfilterchange=3DAutoAdv else AutoAdv() } function AutoAdv() { if(!IsWin("PPTSld") || !gUseSldTimings )return var sld=3DGetCurSld() if( (sld.mAdvDelay>0) && !parent.IsFramesMode() ) setTimeout("parent.GoToNextSld()",sld.mAdvDelay) } function GetObj(id) { if(g_supportsPPTHTML) return document.all(id); else return document.getElementById(id); } function SldHasTrans() { return SlideObj.style.filter !=3D ""; } function GetSldId() { return sId=3Dlocation.href.substring(location.href.la= stIndexOf('/')+1) } function HideMenu() { if( frames["PPTSld"] && PPTSld.document.all.item("ctx= tmenu") && PPTSld.ctxtmenu.style.display!=3D"none" ) { PPTSld.ctxtmenu.styl= e.display=3D'none'; return true } return false } function IsWin( name ) { return window.name =3D=3D name } function IsNts() { return IsWin("PPTNts") } function IsSldOrNts() { return( IsWin("PPTSld")||IsWin("PPTNts") ) } function SupportsPPTAnimation() { return( navigator.platform =3D=3D "Win32"= && navigator.appVersion.indexOf("Windows")>0 ) } function SupportsPPTHTML() { var appVer=3Dnavigator.appVersion, msie=3DappVer.indexOf("MSIE "), ver=3D0 if( msie >=3D 0 ) ver=3DparseFloat( appVer.substring( msie+5, appVer.indexOf(";",msie) ) ) else ver=3DparseInt(appVer) return( ver >=3D 4 && msie >=3D 0 ) } function _RSW() { if( !g_supportsPPTHTML || IsNts() || ( !g_scaleInFrame && (!IsWin("PPTSld") || !parent.IsFullScrMode()) ) ) return var padding=3D0; if( IsWin("PPTSld") && parent.IsFramesMode() ) padding=3D6 cltWidth=3Ddocument.body.clientWidth-padding cltHeight=3Ddocument.body.clientHeight-padding factor=3D(1.0*cltWidth)/g_origW if( cltHeight < g_origH*factor ) factor=3D(1.0*cltHeight)/g_origH newSize =3D g_origSz * factor if( newSize < 1 ) newSize=3D1 s=3DSlideObj.style s.fontSize=3DnewSize+"px" s.posWidth=3Dg_origW*factor s.posHeight=3Dg_origH*factor s.posLeft=3D(cltWidth-s.posWidth+padding)/2 s.posTop=3D(cltHeight-s.posHeight+padding)/2 if( g_scaleHyperlinks ) ScaleHyperlinks( factor ) } function _InitAnimations() { animRuntimeInstalled =3D ''+document.body.localTime !=3D 'undefined'; isFullScreen =3D (window.name =3D=3D "PPTSld") && !parent.IsFramesMode(); g_animUseRuntime =3D g_showAnimation && animRuntimeInstalled && !(isFullSc= reen && parent.IsSldVisited()); if( g_animUseRuntime ) { collSeq =3D document.all.tags("seq"); if( collSeq !=3D null ) { for(ii=3D0;ii numSlds ) gSldJumpIdx =3D numSlds; if ( gSldJumpIdx >=3D 0 ) { if ( gSldJumpIdx =3D=3D 0 ) gSldJumpIdx =3D 1; var jumpTo =3D parseInt(gSldJumpIdx); gSldJump =3D 0; gSldJumpIdx =3D ""; win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref ) } } } function _KDH() { if( event.keyCode =3D=3D 8 ) { event.returnValue =3D 0; parent.GoToPrevSld(); } }function DocumentOnClick() { if( IsNts() || parent.HideMenu() ) return; if( ( g_allowAdvOnClick && (window.name=3D=3D"PPTSld") && !parent.IsFrames= Mode() ) || (event && event.keyCode=3D=3D32) ) { =09 if( g_animUseRuntime && g_animMainSequence && g_animMainSequence.cangonex= t ) return; parent.GoToNextSld(); } } var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""= , g_bgSound=3D"", g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser = =3D 0, gLoopCont =3D 0, gUseSldTimings =3D 1; var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w= indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"End of slide show, click to exit.", SCREEN_MODE=3D"Fram= es", gIsEndShow=3D0, NUM_VIS_SLDS=3D27, SCRIPT_HREF=3D"script.js", FULLSCR_= HREF=3D"fullscreen.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide0036.htm",1,-1,1),new hrefList(= "slide0056.htm",1,-1,1),new hrefList("slide0094.htm",1,-1,1),new hrefList("= slide0038.htm",1,-1,1),new hrefList("slide0106.htm",1,-1,1),new hrefList("s= lide0102.htm",1,-1,1),new hrefList("slide0103.htm",1,-1,1),new hrefList("sl= ide0098.htm",1,-1,1),new hrefList("slide0105.htm",1,-1,1),new hrefList("sli= de0079.htm",1,-1,1),new hrefList("slide0082.htm",1,-1,1),new hrefList("slid= e0107.htm",1,-1,1),new hrefList("slide0088.htm",1,-1,1),new hrefList("slide= 0104.htm",1,-1,1),new hrefList("slide0070.htm",1,-1,1),new hrefList("slide0= 109.htm",1,-1,1),new hrefList("slide0063.htm",1,-1,1),new hrefList("slide01= 10.htm",1,-1,1),new hrefList("slide0066.htm",1,-1,1),new hrefList("slide006= 0.htm",1,-1,1),new hrefList("slide0095.htm",1,-1,1),new hrefList("slide0041= .htm",1,-1,1),new hrefList("slide0065.htm",1,-1,1),new hrefList("slide0096.= htm",1,-1,1),new hrefList("slide0058.htm",1,-1,1),new hrefList("slide0039.h= tm",1,-1,1),new hrefList("slide0097.htm",1,-1,1)); /********************************************* Frameset functions These functions control slide navigation and state of the frameset. **********************************************/ function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) {=09 var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix();=20 function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') {=20 href=3Dnew String(document.location.href)=20 Start=3Dhref.indexOf('!')+1=20 End=3Dhref.lastIndexOf('/')+1=20 if (End < Start)=20 return href.substring(0, Start)=20 else=20 return href.substring(0, End)=20 } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { // Clear any sounds playing before launching another browser window. Other= wise, // in fullscreen mode, you'll continue to hear the sound in the frames mod= e. if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() {=20 if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { =20 obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else =20 return gCurSld } function GetNumSlds() { =20 if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; =09 var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('


' + ENDSHOW_MESG + '

') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); /********************************************* Navigation button implementation There are 2 types of buttons: ImgBtn, TxtBtn implemented as function objects. They share a similiar interface so the event handlers can call SetActive, for example, on a button=20 object without needing to know exactly=20 what type of button it is. **********************************************/ //---------------------------------- function ImgBtn( oId,bId,w,action ) //---------------------------------- { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0=20 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { =20 obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0=20 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } =20 } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } //----------------------------------------- function TxtBtn( oId,oeId,action,chkState ) //----------------------------------------- { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { =20 this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) {=20 if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } =20 } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1=20 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() {=20 b =3D gBtnArr[this.mBorderId]=20 if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() {=20 b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState /********************************************* Context menu implementation _CM() is the function that's hooked up to the oncontextmenu event. Once we're asked to show the menu, we first build it by creating DIVs on-the-fly. Then we position it=20 within the screen area so it doesn't get clipped. Creating the DIVs using createElement() means we don't have to write out any extra HTML into the slide HTML files. **********************************************/ var sNext=3D"Next",sPrev=3D"Previous",sEnd=3D"End Show",sFont=3D"Arial",sAr= row=3D"Arrow",sFreeform=3D"Freeform",sRect=3D"Rectangle",sOval=3D"Oval" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) =09 CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); else GoToNextSld() } function M_GoPrevSld() { if( gIsEndShow ) { gIsEndShow=3D0; history.back();= PPTSld.event.cancelBubble=3Dtrue; } else GoToPrevSld() } function M_True() { return true } function M_End() { window.close( self ) } function CreateMenuItem( node,text,action,eval ) { var e=3DCreateItem( node ) e.type=3D"menuitem" e.Action=3Daction e.IsActive=3Deval e.innerHTML=3Dtext if( !e.IsActive() ) e.style.color=3D"threedshadow" e.onclick=3DPerform e.onmouseover=3DHighlight e.onmouseout=3DDeselect s=3De.style; 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charset="us-ascii" Stimulation of Greenhouse Gas Production resulting from Soil Fumigat= ion and Landfills ------=_NextPart_01C5C2C5.E1FDCE20 Content-Location: file:///C:/0D27C959/OptimizedWang_Toxicology_files/outline.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
 No= tes
Slide Show
Outline
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